Daraprim (B.W. 50-63)--A New Antimalarial

Cryptolepine and development of new antimalarial agents

Natural product-derived drugs exemplified by quinine, isolated from South American Cinchona species and artemisinin discovered in China are of immense importance for the treatment of malaria. Although malaria parasites resistant to artemisinin have not yet been found in malaria patients, the need for new antimalarial agents remains. The burden of malaria is heaviest in Africa where over a milli...

P - PH - 9 50 63 16 B Physics : Theoretical Aspects

Some aspects of B physics relevant for experiments in hadron colliders are discussed. These include the determination of parameters of the CKMMatrix and con rmation of its role in CP violation, studies of mixing of nonstrange and strange B mesons, lifetimes of hadrons containing b quarks, the use of \same-side" tagging of neutral B mesons via correlations with charged pions through fragmentatio...

Cryptolepine and development of new antimalarial agents

Natural product-derived drugs exemplified by quinine, isolated from South American Cinchona species and artemisinin discovered in China are of immense importance for the treatment of malaria. Although malaria parasites resistant to artemisinin have not yet been found in malaria patients, the need for new antimalarial agents remains. The burden of malaria is heaviest in Africa where over a milli...

Pharmacokinetic Study and Bioavailability of a Novel Synthetic Trioxane Antimalarial Compound 97/63 in Rats

Single dose pharmacokinetics study of 97/63 (IND191710, 2004), a trioxane antimalarial developed by Central Drug Research Institute, Lucknow, India, was studied in rats following intravenous and oral administration. Serum samples were analysed by HPLC-UV assay. Separation was achieved on a RP-18 column attached with a guard using acetonitrile : phosphate buffer (70 : 30% v/v) with UV detector a...

Preliminary Report on a New Synthetic Antimalarial